An RNA foldability metric; implications for the design of rapidly foldable RNA sequences

Details An RNA foldability metric; implications for the design of rapidly foldable RNA sequences An RNA foldability metric; implications for the design of rapidly foldable RNA sequences

2005-12-02

arxiv.org/abs/q-bio/0512005v1

Biology

Quantitative Biology

Biomolecules

To appear in Biophysical Chemistry

Scientific paper

10.1016/j.bpc.2005.11.012

Evidence is presented suggesting, for the first time, that the protein foldability metric sigma=(T_theta - T_f)/T_theta, where T_theta and T_f are, respectively, the collapse and folding transition temperatures, could be used also to measure the foldability of RNA sequences. The importance of sigma is discussed in the context of the in silico design of rapidly foldable RNA sequences.

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