An Automatic System to Discriminate Malignant from Benign Massive Lesions on Mammograms

Details An Automatic System to Discriminate Malignant from Benign Massive Lesions on Mammograms An Automatic System to Discriminate Malignant from Benign Massive Lesions on Mammograms

2007-01-04

arxiv.org/abs/physics/0701053v1

Nuclear Instruments and Methods in Physics Research A 569 (2006) 596-600

Physics

Medical Physics

6 pages, 3 figures; Proceedings of the ITBS 2005, 3rd International Conference on Imaging Technologies in Biomedical Sciences,

Scientific paper

10.1016/j.nima.2006.08.093

Mammography is widely recognized as the most reliable technique for early detection of breast cancers. Automated or semi-automated computerized classification schemes can be very useful in assisting radiologists with a second opinion about the visual diagnosis of breast lesions, thus leading to a reduction in the number of unnecessary biopsies. We present a computer-aided diagnosis (CADi) system for the characterization of massive lesions in mammograms, whose aim is to distinguish malignant from benign masses. The CADi system we realized is based on a three-stage algorithm: a) a segmentation technique extracts the contours of the massive lesion from the image; b) sixteen features based on size and shape of the lesion are computed; c) a neural classifier merges the features into an estimated likelihood of malignancy. A dataset of 226 massive lesions (109 malignant and 117 benign) has been used in this study. The system performances have been evaluated terms of the receiver-operating characteristic (ROC) analysis, obtaining A_z = 0.80+-0.04 as the estimated area under the ROC curve.

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