Alternans amplification following a two-stimulations protocol in a one-dimensional cardiac ionic model of reentry: from annihilation to double-wave quasiperiodic reentry

Physics – Biological Physics

Scientific paper

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33 pages, 8 figures, 3 appendices

Scientific paper

Electrical pacing is a common procedure that is used in both experimental and clinical settings for studying and/or annihilating anatomical reentry. In a recent study [Comtois and Vinet, Chaos 12, 903 (2002)], new ways to terminate the one-dimensional reentry using a simple protocol consisting of only two stimulations were discovered. The probability of annihilating the reentrant activity is much more probable by these new scenarios than by the usual local unidirectional block. This paper is an extension of the previous study in which the sensitivity of the new scenarios of annihilation to the pathway length is studied. It follows that reentry can be stopped over a limited interval of the pathway length and that increasing the length beyond the upper limit of this interval yields to a transition to sustained double-wave reentry. A similar dynamical mechanism, labeled alternans amplification, is found to be responsible for both behaviors.

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