Allo-network drugs: harnessing allostery in cellular networks

Details Allo-network drugs: harnessing allostery in cellular networks Allo-network drugs: harnessing allostery in cellular networks

2011-09-23

arxiv.org/abs/1109.5163v2

Trends in Pharmacological Sciences (2011) 32, 686-693

Biology

Quantitative Biology

Molecular Networks

14 pages, 4 figures, 69 references, a cover story of the 2011 December issue of Trends in Pharmacological Sciences

Scientific paper

10.1016/j.tips.2011.08.004

Allosteric drugs are increasingly used because they produce fewer side effects. Allosteric signal propagation does not stop at the 'end' of a protein, but may be dynamically transmitted across the cell. Here, we propose that the concept of allosteric drugs can be broadened to allo-network drugs, whose effects can propagate either within a protein, or across several proteins, to enhance or inhibit specific interactions along a pathway. We posit that current allosteric drugs are a special case of allo-network drugs, and suggest that allo-network drugs can achieve specific, limited changes at the systems level, and in this way can achieve fewer side effects and lower toxicity. Finally, we propose steps and methods to identify allo-network drug targets and sites outlining a new paradigm in systems-based drug design.

Affiliated with

Also associated with

No associations

Rating

Allo-network drugs: harnessing allostery in cellular networks does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Allo-network drugs: harnessing allostery in cellular networks, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Allo-network drugs: harnessing allostery in cellular networks will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-724410