Adaptive optics confocal fluorescence microscopy with direct wavefront sensing for brain tissue imaging

Details Adaptive optics confocal fluorescence microscopy with direct wavefront sensing for brain tissue imaging Adaptive optics confocal fluorescence microscopy with direct wavefront sensing for brain tissue imaging

Feb 2011

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2011spie.7931e..19t&link_type=abstract

MEMS Adaptive Optics V. Edited by Olivier, Scot S.; Bifano, Thomas G.; Kubby, Joel A. Proceedings of the SPIE, Volume 7931, p

Physics

Optics

Scientific paper

Recently, there has been a growing interest in deep tissue imaging for the study of neurons. Unfortunately, because of the inhomogeneous refractive index of the tissue, the aberrations degrade the resolution and brightness of the final image. In this paper, we describe an adaptive optics confocal fluorescence microscope (AOCFM) which can correct aberrations based on direct wavefront measurements using a point source reference beacon and a Shack-Hartmann Wavefront Sensor (SHWS). Mouse brain tissues with different thicknesses are tested. After correction, both the signal intensity and contrast of the image are improved.

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