Physics
Scientific paper
Dec 2006
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2006oleb...36..523s&link_type=abstract
Origins of Life and Evolution of Biospheres, Volume 36, Issue 5-6, pp. 523-531
Physics
4
Formamide, Nucleic Bases, Acyclonucleosides, Informational Polymers, Thermodynamic Niches
Scientific paper
Formamide NH2CHO chemistry provides a unitary frame into which several pieces of the origin-of-life puzzle may be adjusted. Synthetic processes were uncovered which, starting from formamide and prebiotically easily available common catalysts, yield all the necessary nucleic bases precursors, including acyclonucleosides. Formamide allows phosphorylations and trans-phosphorylations, favours the micellar aggregation of surfactants and, most importantly, determines conditions in which the formation of nucleic polymers is thermodynamically favoured. In the detected conditions, the phosphoester bonds are more stable in the polymeric than in the monomeric form, thus allowing formation and survival of informational nucleic polymers.
Ciciriello Fabiana
Costanzo Giovanna
Crestini Claudia
Di Mauro Ernesto
Saladino Raffaele
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