A simplified exactly solvable model for beta-amyloid aggregation

Details A simplified exactly solvable model for beta-amyloid aggregation A simplified exactly solvable model for beta-amyloid aggregation

2010-10-21

arxiv.org/abs/1010.4459v1

Phys. Rev. Lett. 105, 108102 (2010)

Biology

Quantitative Biology

Biomolecules

4 pages, 2 figures

Scientific paper

10.1103/PhysRevLett.105.108102

We propose an exactly solvable simplified statistical mechanical model for the thermodynamics of beta-amyloid aggregation, generalizing a well-studied model for protein folding. The monomer concentration is explicitly taken into account as well as a non trivial dependence on the microscopic degrees of freedom of the single peptide chain, both in the alpha-helix folded isolated state and in the fibrillar one. The phase diagram of the model is studied and compared to the outcome of fibril formation experiments which is qualitatively reproduced.

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