A Physiologically-Based Flow Network Model for Hepatic Drug Elimination I: Regular Lattice Lobule Model

Details A Physiologically-Based Flow Network Model for Hepatic Drug Elimination I: Regular Lattice Lobule Model A Physiologically-Based Flow Network Model for Hepatic Drug Elimination I: Regular Lattice Lobule Model

2011-11-04

arxiv.org/abs/1111.1228v1

Physics

Biological Physics

19 pages, 14 figures

Scientific paper

We develop a physiologically-based lattice model for the transport and metabolism of drugs in the functional unit of the liver, called the lobule. In contrast to earlier studies, we have emphasized the dominant role of convection in well-vascularized tissue with a given structure. Estimates of convective, diffusive and reaction contributions are given. We have compared drug concentration levels observed exiting the lobule with their predicted detailed distribution inside the lobule, assuming that most often the former is accessible information while the latter is not.

Affiliated with

Also associated with

No associations

Rating

A Physiologically-Based Flow Network Model for Hepatic Drug Elimination I: Regular Lattice Lobule Model does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with A Physiologically-Based Flow Network Model for Hepatic Drug Elimination I: Regular Lattice Lobule Model, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and A Physiologically-Based Flow Network Model for Hepatic Drug Elimination I: Regular Lattice Lobule Model will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-101871