A non-equilibrium dynamic mechanism for the allosteric effect

Details A non-equilibrium dynamic mechanism for the allosteric effect A non-equilibrium dynamic mechanism for the allosteric effect

2007-03-07

arxiv.org/abs/physics/0703089v3

Phys. Rev. Lett. 99, 168103 (2007)

Physics

Biological Physics

accepted by Phys. Rev. Lett. Major revisions were made to fit the style. 4 pages, 2 figures

Scientific paper

10.1103/PhysRevLett.99.168103

Allosteric regulation is often viewed as thermodynamic in nature. However protein internal motions during an enzymatic reaction cycle can be slow hopping processes over numerous potential barriers. We propose that regulating molecules may function by modifying the nonequilibrium protein dynamics. The theory predicts that an enzyme under the new mechanism has different temperature dependence, waiting time distribution of the turnover cycle, and dynamic fluctuation patterns with and without effector. Experimental tests of the theory are proposed.

Affiliated with

Also associated with

No associations

Rating

A non-equilibrium dynamic mechanism for the allosteric effect does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with A non-equilibrium dynamic mechanism for the allosteric effect, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and A non-equilibrium dynamic mechanism for the allosteric effect will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-642848