Biology – Quantitative Biology – Molecular Networks
Scientific paper
2010-07-28
Journal of Biological Systems, 19, 299-317, 2011
Biology
Quantitative Biology
Molecular Networks
15 pages, 1 figure, 1 table
Scientific paper
10.1142/S0218339011003919
Our main tenet argues that the primary role of positive thymic selection and the resulting T cell population is the maintenance of a homeostatic equilibrium with self MHC-self peptide complexes. The homeostatic T cell repertoire can recognize infections non-specifically and this is an indirect (negative) recognition: the whole homeostatic T cell population together "holds a mirror" to the whole self, and any MHC-peptide complex that is "not reflected in the mirror" can be perceived by surrounding homeostatic T cells as a signal of the presence of a foreign entity. On the other hand, infection-specific T cell clones arise in a different pathway in the periphery, do not enter the thymus, and form a functionally different population. Here we summarize the basic assumptions and consequences of a logic-based new model, which differs from conventional models in many respects.
Bakacs Tibor
Szabados Tamás
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