A helicoidal transfer matrix model for inhomogeneous DNA melting

Details A helicoidal transfer matrix model for inhomogeneous DNA melting A helicoidal transfer matrix model for inhomogeneous DNA melting

2005-07-25

arxiv.org/abs/q-bio/0507036v3

Phys. Rev. E 73, 011908 (2006)

Biology

Quantitative Biology

Biomolecules

v3: Matlab toolbox included with source file; article unchanged, 12 pages, 11 figures, RevTeX

Scientific paper

10.1103/PhysRevE.73.011908

An inhomogeneous helicoidal nearest-neighbor model with continuous degrees of freedom is shown to predict the same DNA melting properties as traditional long-range Ising models, for free DNA molecules in solution, as well as superhelically stressed DNA with a fixed linking number constraint. Without loss of accuracy, the continuous degrees of freedom can be discretized using a minimal number of discretization points, yielding an effective transfer matrix model of modest dimension (d=36). The resulting algorithms to compute DNA melting profiles are both simple and efficient.

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