A Growth Model for Multicellular Tumor Spheroids

Details A Growth Model for Multicellular Tumor Spheroids A Growth Model for Multicellular Tumor Spheroids

2003-07-29

arxiv.org/abs/physics/0307136v1

Physics

Biological Physics

Scientific paper

10.1063/1.1812842

Most organisms grow according to simple laws, which in principle can be derived from energy conservation and scaling arguments, critically dependent on the relation between the metabolic rate B of energy flow and the organism mass m. Although this relation is generally recognized to be of the form B(m) = mp, the specific value of the exponent p is the object of an ongoing debate, with many mechanisms being postulated to support different predictions. We propose that multicellular tumor spheroids provide an ideal experimental model system for testing these allometric growth theories, especially under controlled conditions of malnourishment and applied mechanical stress.

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