A Coarse-Grained Lattice Model for Molecular Recognition

Details A Coarse-Grained Lattice Model for Molecular Recognition A Coarse-Grained Lattice Model for Molecular Recognition

2006-08-24

arxiv.org/abs/physics/0608234v1

Phys. Rev. Lett. 97, 128101 (2006)

Physics

Biological Physics

4 pages, 3 figures, to appear in Phys. Rev. Lett

Scientific paper

10.1103/PhysRevLett.97.128101

We present a simple model which allows to investigate equilibrium aspects of molecular recognition between rigid biomolecules on a generic level. Using a two-stage approach, which consists of a design and a testing step, the role of cooperativity and of varying bond strength in molecular recognition is investigated. Cooperativity is found to enhance selectivity. In complexes which require a high binding flexibility a small number of strong bonds seems to be favored compared to a situation with many but weak bonds.

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