A bistable mechanism for directional sensing

Details A bistable mechanism for directional sensing A bistable mechanism for directional sensing

Aug 2008

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2008njph...10h3015b&link_type=abstract

New Journal of Physics, Volume 10, Issue 8, pp. 083015 (2008).

Physics

2

Scientific paper

We present a generic mechanism for directional sensing in eukaryotic cells that is based on bistable dynamics. As the key feature of this modeling approach, the velocity of trigger waves in the bistable sensing system changes its sign across cells that are exposed to an external chemoattractant gradient. This is achieved by combining a two-component activator/inhibitor system with a bistable switch that induces an identical symmetry breaking for arbitrary gradient input signals. A simple kinetic example is designed to illustrate the dynamics of a bistable directional sensing mechanism in numerical simulations.

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