Physics – Optics
Scientific paper
Feb 1999
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1999spie.3537....0h&link_type=abstract
Proc. SPIE Vol. 3537, p. 0-7, Electro-Optic, Integrated Optic, and Electronic Technologies for Online Chemical Process Monitorin
Physics
Optics
6
Scientific paper
Recent developments in the field of integrated optics have resulted in an innovative class of microsensors, exhibiting chemical and biochemical sensing capabilities comparable to that of sophisticated analytical laboratory instrumentation in many instances. The sensing capability results from a novel integrated optic (IO) interferometric transducer design using biomolecular receptor agents and/or chemically selective agents bound to the waveguide surface. The IO interferometer's ability to detect refractive index changes of less than 10-6 opens the door to a new class of sensing chemistries, including active surface chemistries, which offer enhanced detection capabilities for selected chem/bio agents. The sensor exhibits rapid response (less than 0.1 seconds in the case of specific chemicals), trace level detection sensitivity (parts-per-billion by volume or femtomolar levels), and multiple sensing channels, thirteen at present, for multianalyte sensing on a 1 cm X 3-cm chip. In this paper, the integrated optic interferometric sensor design, fabrication and performance are discussed.
Cobb Janet M.
Edwards John G.
Hartman Nile F.
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