Template-directed chemistry and the origins of the RNA world

Details Template-directed chemistry and the origins of the RNA world Template-directed chemistry and the origins of the RNA world

Nov 1994

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1994oleb...24..479k&link_type=abstract

Origins of Life and Evolution of the Biosphere, Volume 24, Issue 6, pp.479-494

Physics

5

Scientific paper

Prompted by the growing number of reports about reactions catalyzed by ribozymes, this paper summarizes mechanistic and kinetic aspects of template-directed (TD) chemistry important for the synthesis of a diverse population of polynucleotides and analogues possibly up to 100 units long. Assuming that this chemistry takes place in a microenvironment conducive to life under the constant influx of mM concentrations of activated monomeric building blocks, the proposed scenario represents a working hypothesis for the prebiotic synthesis of the RNA world.

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