Importance of Pyrimidine Derivatives in the Growth of Group C (Lancefield) Streptococci upon a Simplified Medium

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Scientific paper

RICHARDSON1 showed that uracil (2.6 dihydroxy pyrimidine) is necessary for the anaerobic growth of Staphylococcus aureus, and more recently Snell and Mitchell2 have reported that purine and pyrimidine derivatives stimulate the growth of certain lactic acid bacteria. Möller3 had previously claimed that adenine and guanine increase the growth of Lactobacillus plantanum. Pappenheimer and Hottle4 showed that uracil is not necessary for the growth of a strain of hæmolytic streptococcus Group A. The latter authors reported, however, that purine derivatives are necessary for this organism unless the carbon dioxide tension in the atmosphere above the culture is high. At a partial pressure of 40 mm. mercury of this gas, rapid and optimal growth occurs without the addition of purines to the medium.

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