Prebiotic synthesis and organization of biopolymer-like macromolecules

Physics

Scientific paper

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Scientific paper

Prebiotic synthesis of bio-oligomers containing more than five units are examined with respect to chemical divergence and physical dispersion of the products. Experiments are presented which support a possible pathway running from a primitive mixture of amino acids to peptides organized into stereospecific β-sheet surfaces. This pathway includes selective condensation of amino acids through the racemization-free N-carboxyanhydride polymerization, specific aggregation of alternating sequences with hydrophilic and hydrophobic residues and enantioselection of homochiral sequences.

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