Coupled dynamics of voltage and calcium in paced cardiac cells

Details Coupled dynamics of voltage and calcium in paced cardiac cells Coupled dynamics of voltage and calcium in paced cardiac cells

2004-05-11

arxiv.org/abs/physics/0405048v1

Physics

Biological Physics

Scientific paper

10.1103/PhysRevE.71.021903

We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model and its reduction to a three-dimensional discrete map. The results provide a theoretical framework to interpret various experimentally observed modes of instability ranging from electromechanically concordant and discordant alternans to quasiperiodic oscillations of voltage and calcium.

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