Electric field-controlled water permeation coupled to ion transport through a nanopore

Details Electric field-controlled water permeation coupled to ion transport through a nanopore Electric field-controlled water permeation coupled to ion transport through a nanopore

2003-05-30

arxiv.org/abs/physics/0305135v1

Journal of Chemical Physics 120, 5001 (2004)

Physics

Biological Physics

4 pages, 4 figures

Scientific paper

10.1063/1.1665656

We report Molecular Dynamics (MD) simulations of a generic hydrophobic nanopore connecting two reservoirs which are initially at different Na+ concentrations, as in a biological cell. The nanopore is impermeable to water under equilibrium conditions, but the strong electric field caused by the ionic concentration gradient drives water molecules in. The density and structure of water in the pore are highly field dependent. In a typical simulation run, we observe a succession of cation passages through the pore, characterized by approximately bulk mobility. These ion passages reduce the electric field, until the pore empties of water and closes to further ion transport, thus providing a possible mechanism for biological ion channel gating.

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