Dynamical modelling of molecular constructions and setups for DNA unzipping

Details Dynamical modelling of molecular constructions and setups for DNA unzipping Dynamical modelling of molecular constructions and setups for DNA unzipping

2008-12-05

arxiv.org/abs/0812.1180v1

Phys. Biol. 6, 025003 (2009)

Biology

Quantitative Biology

Biomolecules

Scientific paper

10.1088/1478-3975/6/2/025003

We present a dynamical model of DNA mechanical unzipping under the action of a force. The model includes the motion of the fork in the sequence-dependent landscape, the trap(s) acting on the bead(s), and the polymeric components of the molecular construction (unzipped single strands of DNA, and linkers). Different setups are considered to test the model, and the outcome of the simulations is compared to simpler dynamical models existing in the literature where polymers are assumed to be at equilibrium.

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