Three faces of metabolites: Pathways, localizations and network positions

Details Three faces of metabolites: Pathways, localizations and network positions Three faces of metabolites: Pathways, localizations and network positions

2009-07-22

arxiv.org/abs/0907.3927v1

Biology

Quantitative Biology

Molecular Networks

Scientific paper

To understand the system-wide organization of metabolism, different lines of study have devised different categorizations of metabolites. The relationship and difference between categories can provide new insights for a more detailed description of the organization of metabolism. In this study, we investigate the relative organization of three categorizations of metabolites -- pathways, subcellular localizations and network clusters, by block-model techniques borrowed from social-network studies and further characterize the categories from topological point of view. The picture of the metabolism we obtain is that of peripheral modules, characterized both by being dense network clusters and localized to organelles, connected by a central, highly connected core. Pathways typically run through several network clusters and localizations, connecting them laterally. The strong overlap between organelles and network clusters suggest that these are natural "modules" -- relatively independent sub-systems. The different categorizations divide the core metabolism differently suggesting that this, if possible, should be not be treated as a module on par with the organelles. Although overlapping more than chance, none of the pathways correspond very closely to a network cluster or localization. This, we believe, highlights the benefits of different orthogonal classifications and future experimental categorizations based on simple principles.

Affiliated with

Also associated with

No associations

Rating

Three faces of metabolites: Pathways, localizations and network positions does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Three faces of metabolites: Pathways, localizations and network positions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Three faces of metabolites: Pathways, localizations and network positions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-354168