Kinesin as an electrostatic machine

Details Kinesin as an electrostatic machine Kinesin as an electrostatic machine

2006-10-24

arxiv.org/abs/q-bio/0610045v1

Biology

Quantitative Biology

Biomolecules

6 pages, 3 figures. To appear in the Journal of Biological Physics

Scientific paper

10.1007/s10867-006-9028-6

Kinesin and related motor proteins utilize ATP fuel to propel themselves along the external surface of microtubules in a processive and directional fashion. We show that the observed step-like motion is possible through time varying charge distributions furnished by the ATP hydrolysis circle while the static charge configuration on the microtuble provides the guide for motion. Thus, while the chemical hydrolysis energy induces appropriate local conformational changes, the motor translational energy is fundamentally electrostatic. Numerical simulations of the mechanical equations of motion show that processivity and directionality are direct consequences of the ATP-dependent electrostatic interaction between the different charge distributions of kinesin and microtubule.

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