Spectral Analysis of Protein-Protein Interactions in Drosophila melanogaster

Details Spectral Analysis of Protein-Protein Interactions in Drosophila melanogaster Spectral Analysis of Protein-Protein Interactions in Drosophila melanogaster

2004-05-26

arxiv.org/abs/q-bio/0405021v1

Biology

Quantitative Biology

Molecular Networks

9 pages RevTeX including 8 figures

Scientific paper

10.1103/PhysRevE.71.041911

Within a case study on the protein-protein interaction network (PIN) of Drosophila melanogaster we investigate the relation between the network's spectral properties and its structural features such as the prevalence of specific subgraphs or duplicate nodes as a result of its evolutionary history. The discrete part of the spectral density shows fingerprints of the PIN's topological features including a preference for loop structures. Duplicate nodes are another prominent feature of PINs and we discuss their representation in the PIN's spectrum as well as their biological implications.

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