Promotion of a new radioprotective antioxidative agent

Details Promotion of a new radioprotective antioxidative agent Promotion of a new radioprotective antioxidative agent

May 1989

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1989aipc..186..434m&link_type=abstract

HIGH-ENERGY RADIATION BACKGROUND IN SPACE. AIP Conference Proceedings, Volume 186, pp. 434-441 (1989).

Physics

Medical Physics

Aerospace Bio- And Medical Physics

Scientific paper

Radioprotective effects of pre- and post-irradiation treatments giving zinc manganese, or one of biological response modifiers (BRMs), or subjecting mice to stressful conditions on the whole bodily irradiated mice were investigated with respect to MT induction.
The normal level of MT in murine liver is as low a 1-2 nano mole/g tissue, but the level can be elevated to several or even twenty times after the administration of a heavy metal or a certain BRM or both. A stress, e.g. dermal excision also induced hepatic MT synthesis.
These pretreatments to induce hepatic MT gave a strong tolerance against lethal damage to mice. The effect of combined use of BRM with manganese or zinc was more prominent. Since manganese has less adverse effects and easily eliminated from organs, the spot administration of even after the irradiation was considerably effective. Mice administered manganese manifested a quicker regaining in the number of leucocytes and erythrocyted than control mice.
These investigations suggested us a possibility that man can promote their body defense mechanism through the induction of MT in the organs by a certain stimulative measure e.g. the administration of a certain less harmful metal or chemicals, physical exercises or controlling various factors in our environment. Since the induction of MT by taking advantage of body's own biological protection mechanism is versatile with almost no adverse effects, it may opens new vistas of radiation protection in the future.

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