Physics
Scientific paper
Apr 1967
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1967natur.214..206c&link_type=abstract
Nature, Volume 214, Issue 5084, pp. 206-207 (1967).
Physics
Scientific paper
WE have observed periodic oscillations in systemic blood pressure synchronous with bursts of phrenic nerve activity in dogs during apnoea. The phrenic nerve was isolated in the neck, and nerve impulses detected with bipolar platinum electrodes. The nervous activity was amplified and rectified, and the impulses integrated by a method described previously1. Catheters were placed in both femoral arteries to record the arterial blood pressure continuously as well as to sample arterial blood so as to measure the arterial carbon dioxide tension every minute. Spontaneous breathing was arrested by the intravenous administration of succinyl choline, and the dogs were ventilated artificially with 100 per cent oxygen for twenty minutes using a Harvard pump. Initial measurements of carbon dioxide tension and phrenic nerve activity were made at the end of this control period. Artificial ventilation was then stopped and the dog connected by its endotracheal tube to a spirometer containing 100 per cent oxygen. By this means arterial oxygen was maintained at normal tension during the ensuing period of apnoea, when carbon dioxide tension increased at the rate of 6.0 mm of mercury/min.
Cherniack Neil S.
Chisholm Joseph C.
Heymann Mark
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