Physics
Scientific paper
Feb 1995
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1995sci...267..643i&link_type=abstract
Science, Volume 267, Issue 5198, pp. 643-647
Physics
14
Scientific paper
An RNA has been selected that rapidly aminoacylates its 2'(3' terminus when provided with phenylalanyl-adenosine monophosphate. That is, the RNA accelerates the same aminoacyl group transfer catalyzed by protein aminoacyl-transfer RNA synthetases. The best characterized RNA reaction requires both Mg2+ and Ca2+. These results confirm a necessary prediction of the RNA world hypothesis and represent efficient RNA reaction (>=10^5 times accelerated) at a carbonyl carbon, exemplifying a little explored type of RNA catalysis.
Illangasekare Mali
Nickles Tim
Sanchez Giselle
Yarus Michael
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