Search for catalytic properties of simple polypeptides

Details Search for catalytic properties of simple polypeptides Search for catalytic properties of simple polypeptides

Sep 1987

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1987orli...17..381b&link_type=abstract

Origins of Life and Evolution of the Biosphere, Volume 17, Issue 3-4, pp. 381-390

Physics

2

Scientific paper

Simple polypeptides were used as possible supports for nucleotide polymerization, in the absence of any preformed polynucleotide template. Sequential copolymers of alanine and glycine, water soluble polypeptides based on arginine and poly(Glu-SerGlu) have been tested. No catalytic effect has been found although poly(Glu-Ser-Glu) favors the 2' 5' internucleotide linkage. More interestingly, polypeptides containing arginine residues strongly accelerate the hydrolysis of oligoadenylic acids. The influence of pH, temperature, nature of the buffer and polypeptide sequence was investigated.

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