Derivatization and Template-Guided Ligation of Oligodeoxyribonucleotides Using Cyanogen Bromide and N-Substituted Morpholines

Details Derivatization and Template-Guided Ligation of Oligodeoxyribonucleotides Using Cyanogen Bromide and N-Substituted Morpholines Derivatization and Template-Guided Ligation of Oligodeoxyribonucleotides Using Cyanogen Bromide and N-Substituted Morpholines

Dec 1997

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1997oleb...27..555s&link_type=abstract

Origins of Life and Evolution of the Biosphere, v. 27, Issue 5/6, p. 555-566 (1997).

Physics

Scientific paper

Cyanogen bromide has been found to induce the template-guided condensation of oligonucleotides only in the presence of N-substituted morpholines. Based on ^31P, ^1H and ^13C NMR spectroscopy data, the mechanism of the phosphomonoester group activation by cyanogen bromide in N-substituted morpholine buffers is suggested. It has also been shown that BrCN can be used for the synthesis of oligonucleotide derivatives in aqueous solution.

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