Peptide-Formation on Cysteine-Containing Peptide Scaffolds

Details Peptide-Formation on Cysteine-Containing Peptide Scaffolds Peptide-Formation on Cysteine-Containing Peptide Scaffolds

Oct 1999

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1999oleb...29..441c&link_type=abstract

Origins of Life and Evolution of the Biosphere, v. 29, Issue 5, p. 441-449 (1999).

Physics

2

Scientific paper

Monomeric cysteine residues attached to cysteine-containing peptides by disulfide bonds can be activated by carbonyldiimidazole. If two monomeric cysteine residues, attached to a `scaffold' peptide Gly-Cys-Gly_n-Cys-Glu_10, (n = 0, 1, 2, 3) are activated, they react to form the dipeptide Cys-Cys. in 25-65% yield. Similarly, the activation of a cysteine residue attached to the `scaffold' peptide Gly-Cys-Gly-Glu_10 in the presence of Arg_5 leads to the formation of Cys-Arg_5 in 50% yield. The significance of these results for prebiotic chemistry is discussed.

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