Low-Field MRI and Functional Lung Imaging Using Laser Polarized Noble Gases

Details Low-Field MRI and Functional Lung Imaging Using Laser Polarized Noble Gases Low-Field MRI and Functional Lung Imaging Using Laser Polarized Noble Gases

Mar 1999

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1999aps..cntec3203w&link_type=abstract

American Physical Society, Centennial Meeting, March 20-26, 1999, Atlanta, GA, Bulletin of the American Physical Society, Vol.

Physics

Scientific paper

Large nuclear spin polarizations can be created in dense samples of the spin 1/2 noble gases (^3He and ^129Xe) using laser optical pumping techniques. Such large spin polarization greatly enhances the nuclear magnetic resonance (NMR) detection sensitivity of these noble gases, providing a powerful new tool for biomedical investigations. I will discuss two of our current research activities using this new technique: magnetic resonance imaging (MRI) of laser polarized ^3He in the lung gas space at low magnetic fields (20 G); and mapping of the surface area of the lung by NMR measurements of the exchange of laser polarized ^129Xe between the gas and dissolved-tissue phases.

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