Influence of Cadmium and Other Trace Metals on Human α 1-Antitrypsin: An in vitro Study

Details Influence of Cadmium and Other Trace Metals on Human α 1-Antitrypsin: An in vitro Study Influence of Cadmium and Other Trace Metals on Human α 1-Antitrypsin: An in vitro Study

Feb 1976

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1976sci...191..480c&link_type=abstract

Science, Volume 191, Issue 4226, pp. 480-481

Physics

1

Scientific paper

The effect of trace metals on plasma α 1-antitrypsin was studied in vitro by adding known concentrations of trace metals, either alone or in combination, to plasma. Cadmium was the only trace metal that reduced the concentration of α 1-antitrypsin and depressed the trypsin inhibitory capacity. No such effects were found with divalent lead, mercury, nickel, iron, and zinc ions. The present study appears to offer a plausible explanation for the emphysema that occurs in industrial workers exposed to cadmium.

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