Computer Science
Scientific paper
Sep 1978
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1978orli....9...39w&link_type=abstract
Origins of Life, Volume 9, Issue 1, pp.39-50
Computer Science
7
Scientific paper
A correlation of various aspects of the protein structures and substrate and mechanistic specificities of the aminoacyl-tRNA synthetases has led to the identification of at least one family of enzymes probably derived from a common ancestral synthetase. While strong correlations exist only in one part of the array of 64 codons comprising the Genetic Code, this itself may be interpreted as a meaningful pattern, most consistent with a development of the present code from earlier codes containing fewer amino acids and fewer available codons. Specifically, strong correlations in the enzymes whose cognate tRNAs respond to codons containing a central pyrimidine, including the enzyme family of Ile-, Phe-, Val-, Met-, and Leu-tRNA synthetases, suggests that these enzymes evolved last, and that, therefore, an earlier version of the Genetic Code was comprised solely of codons containing a central purine. It is suggested that further study of the historical interrelationships of these enzymes could lead to a fairly detailed picture of how the Genetic Code developed.
No associations
LandOfFree
Aminoacyl-tRNA synthetase families and their significance to the origin of the genetic code does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Aminoacyl-tRNA synthetase families and their significance to the origin of the genetic code, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aminoacyl-tRNA synthetase families and their significance to the origin of the genetic code will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-942891