Mathematics – Logic
Scientific paper
Jan 1984
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1984natur.307..376j&link_type=abstract
Nature, Volume 307, Issue 5949, pp. 376-378 (1984).
Mathematics
Logic
Scientific paper
The shape of the human erythrocyte depends on intracellular ATP content1,2 and echinocytic erythrocyte ghosts obtained in the presence of Mg-ATP acquire a diskocytic shape3-5 after incubation at 37 °C however, agreement is lacking about the molecular basis of the shape changes. The suggestion that phosphorylation of cytoskeletal structures underlying the membrane is involved5,6 has been disputed and alternative explanations based on lipid bilayer theory7,8 and metabolism of phospholipid9,10 have been proposed. Recently, we re-examined the effect of ATP on the shape of ghosts and found that it consists of two distinct steps11. We have, therefore, now examined the effect of physiological concentrations of Ca2+ and ATP on the cytoskeleton of the erythrocyte membrane directly using Triton-treated ghosts which had lost this permeability barrier. Our findings suggest that a noncovalent effect of ATP on the cytoskeleton is a prerequisite for shape change.
Jinbu Yoshinosri
Nakao Makoto
Sato Shingo
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