Senescence Can Explain Microbial Persistence

Details Senescence Can Explain Microbial Persistence Senescence Can Explain Microbial Persistence

2006-10-13

arxiv.org/abs/q-bio/0610026v1

Biology

Quantitative Biology

Cell Behavior

16 pages

Scientific paper

It has been known for many years that small fractions of persister cells resist killing in many bacterial colony-antimicrobial confrontations. These persisters are not believed to be mutants. Rather it has been hypothesized that they are phenotypic variants. Current models allow cells to switch in and out of the persister phenotype. Here we suggest a different explanation, namely senescence, for persister formation. Using a mathematical model including age structure, we show that senescence provides a natural explanation for persister-related phenomena including the observations that persister fraction depends on growth phase in batch culture and dilution rate in continuous culture.

Affiliated with

Also associated with

No associations

Rating

Senescence Can Explain Microbial Persistence does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Senescence Can Explain Microbial Persistence, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Senescence Can Explain Microbial Persistence will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-90046