Mutagenic effects of solar UV-radiation on DNA

Details Mutagenic effects of solar UV-radiation on DNA Mutagenic effects of solar UV-radiation on DNA

Aug 2001

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2001esasp.496..393r&link_type=abstract

In: Exo-/astro-biology. Proceedings of the First European Workshop, 21 - 23 May 2001, ESRIN, Frascati, Italy. Eds.: P. Ehrenfreu

Biology

Solar Uv Radiation, Mutagenic Effects

Scientific paper

A decrease of the stratospheric ozone layer will result in an increase of shorter wavelengths of the solar radiation reaching in earth. To investigate the biological efficiency, especially the mutagenic specificity, of ranges of polychromatic UVA and UBV irradiations with wavelengths between 280 nm and 400 nm, the plasmid DNA pUC19 and its E. coli host strain JM83 were used as a model system. Different ranges of solar UV radiation were simulated with the SOL 2 sun simulator (Dr. Hönle) and a variety of cut-off filters (Schott). Three wavelength bands were investigated: 280 - 400 nm (simulating UV-range under a stratospheric ozone layer depletion), 300-400 nm (simulating the UV-range today) and 315-400 nm to examine the effects induced by UVA alone.

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