Biology – Quantitative Biology – Populations and Evolution
Scientific paper
2011-05-05
J. Stat. Mech. (2011) P08018
Biology
Quantitative Biology
Populations and Evolution
11 pages, 3 figures
Scientific paper
10.1088/1742-5468/2011/08/P08018
An explicit solution for a general two-type birth-death branching process with one way mutation is presented. This continuous time process mimics the evolution of resistance to treatment, or the onset of an extra driver mutation during tumor progression. We obtain the exact generating function of the process at arbitrary times, and derive various large time scaling limits. In the simultaneous small mutation rate and large time scaling limit, the distribution of the mutant cells develops some atypical properties, including a power law tail and diverging average.
Antal Tibor
Krapivsky Paul. L.
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