MOST: detecting cancer differential gene expression

Details MOST: detecting cancer differential gene expression MOST: detecting cancer differential gene expression

2007-09-10

arxiv.org/abs/0709.1307v1

Biostatistics, 2008 9(3):411-418

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We propose a new statistics for the detection of differentially expressed genes, when the genes are activated only in a subset of the samples. Statistics designed for this unconventional circumstance has proved to be valuable for most cancer studies, where oncogenes are activated for a small number of disease samples. Previous efforts made in this direction include COPA, OS and ORT. We propose a new statistics called maximum ordered subset t-statistics (MOST) which seems to be natural when the number of activated samples is unknown. We compare MOST to other statistics and find the proposed method often has more power then its competitors.

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