Capacitance fluctuations causing channel noise reduction in stochastic Hodgkin-Huxley systems

Biology – Quantitative Biology – Neurons and Cognition

Scientific paper

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

18 pages

Scientific paper

10.1088/1478-3975/3/4/002

Voltage-dependent ion channels determine the electric properties of axonal cell membranes. They not only allow the passage of ions through the cell membrane but also contribute to an additional charging of the cell membrane resulting in the so-called capacitance loading. The switching of the channel gates between an open and a closed configuration is intrinsically related to the movement of gating charge within the cell membrane. At the beginning of an action potential the transient gating current is opposite to the direction of the current of sodium ions through the membrane. Therefore, the excitability is expected to become reduced due to the influence of a gating current. Our stochastic Hodgkin-Huxley like modeling takes into account both the channel noise -- i.e. the fluctuations of the number of open ion channels -- and the capacitance fluctuations that result from the dynamics of the gating charge. We investigate the spiking dynamics of membrane patches of variable size and analyze the statistics of the spontaneous spiking. As a main result, we find that the gating currents yield a drastic reduction of the spontaneous spiking rate for sufficiently large ion channel clusters. Consequently, this demonstrates a prominent mechanism for channel noise reduction.

No associations

LandOfFree

Say what you really think

Search LandOfFree.com for scientists and scientific papers. Rate them and share your experience with other people.

Rating

Capacitance fluctuations causing channel noise reduction in stochastic Hodgkin-Huxley systems does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Capacitance fluctuations causing channel noise reduction in stochastic Hodgkin-Huxley systems, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Capacitance fluctuations causing channel noise reduction in stochastic Hodgkin-Huxley systems will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFWR-SCP-O-566675

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.