How occasional backstepping can speed up a processive motor protein

Details How occasional backstepping can speed up a processive motor protein How occasional backstepping can speed up a processive motor protein

2008-04-13

arxiv.org/abs/0804.2055v1

Biology

Quantitative Biology

Subcellular Processes

LaTeX, 5 pages, 3 figures

Scientific paper

10.1016/j.bpj.2008.12.620

Fueled by the hydrolysis of ATP, the motor protein kinesin literally walks on two legs along the biopolymer microtubule. The number of accidental backsteps that kinesin takes appears to be much larger than what one would expect given the amount of free energy that ATP hydrolysis makes available. This is puzzling as more than a billion years of natural selection should have optimized the motor protein for its speed and efficiency. But more backstepping allows for the production of more entropy. Such entropy production will make free energy available. With this additional free energy, the catalytic cycle of the kinesin can be speeded up. We show how measured backstep percentages represent an optimum at which maximal net forward speed is achieved.

Affiliated with

Also associated with

No associations

Rating

How occasional backstepping can speed up a processive motor protein does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with How occasional backstepping can speed up a processive motor protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and How occasional backstepping can speed up a processive motor protein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-506058