Robust and Irreversible Development in Cell Society as a General Consequence of Intra-Inter Dynamics

Nonlinear Sciences – Adaptation and Self-Organizing Systems

Scientific paper

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17 pages with 3 ps figures. submitted to Physica A as a proceeding paperfor Paladin Memorial Conf

Scientific paper

10.1016/S0378-4371(99)00615-9

A dynamical systems scenario for developmental cell biology is proposed, based on numerical studies of a system with interacting units with internal dynamics and reproduction. Diversification, formation of discrete and recursive types, and rules for differentiation are found as a natural consequence of such a system. "Stem cells" that either proliferate or differentiate to different types stochastically are found to appear when intra-cellular dynamics are chaotic. Robustness of the developmental process against microscopic and macroscopic perturbations is shown to be a natural consequence of such intra-inter dynamics, while irreversibility in developmental process is discussed in terms of the gain of stability, loss of diversity and chaotic instability.

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