Biology – Quantitative Biology – Neurons and Cognition
Scientific paper
2005-05-16
Biology
Quantitative Biology
Neurons and Cognition
This is a PhD dissertation
Scientific paper
The studies described in this dissertation have attempted to address the cellular mechanisms of information storage by the brain. My work has focused primarily on the postsynaptic events that occur during and after induction of long-term potentiation (LTP) and long-term depression (LTD) at the Schaffer collateral-CA1 synapse of the hippocampus. I have explored various aspects of the role of postsynaptic Ca$^{2+}$ in the induction of LTP and LTD using both extracellular and whole-cell recording techniques, as well as fluorescence imaging of Ca$^{2+}$. I have also examined the possible role of modulation of dendritic K$^{+}$ channels in the induction of LTP.
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