Ion Concentration Dynamics as a Mechanism for Neuronal Bursting

Details Ion Concentration Dynamics as a Mechanism for Neuronal Bursting Ion Concentration Dynamics as a Mechanism for Neuronal Bursting

2010-12-14

arxiv.org/abs/1012.3124v3

Biology

Quantitative Biology

Cell Behavior

The most recent version now contains citation information: Journal of Biological Physics 37, 361-373 (2011)

Scientific paper

10.1007/s10867-010-9212-6

We describe a simple conductance-based model neuron that includes intra- and extra-cellular ion concentration dynamics and show that this model exhibits periodic bursting. The bursting arises as the fast spiking behavior of the neuron is modulated by the slow oscillatory behavior in the ion concentration variables, and vice versa. By separating these time scales and studying the bifurcation structure of the neuron, we catalog several qualitatively different bursting profiles that are strikingly similar to those seen in experimental preparations. Our work suggests that ion concentration dynamics may play an important role in modulating neuronal excitability in real biological systems.

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