Intranuclear Localization of Mercury in vivo

Details Intranuclear Localization of Mercury in vivo Intranuclear Localization of Mercury in vivo

Nov 1974

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1974sci...186..832b&link_type=abstract

Science, Volume 186, Issue 4166, pp. 832-833

Computer Science

Scientific paper

Purified nuclei isolated from mice challenged with nonlethal levels of mercury chloride (10-3M) in drinking water for 4 to 7 weeks (experimental) and from animals given deionized water (control) were fractionated and the subsequent fractions were analyzed for mercury by flameless atomic absorption. Control (active) euchromatin contained 1.75 ± 0.53 micrograms of mercury per milligram of DNA. There was a 12- to 15-fold enrichment of mercury in the euchromatin fraction of challenged animals. Mercury was not detected in control (inactive) heterochromatin, and only trace levels (parts per billion) appeared in experimental heterochromatin. It seems likely that mercury can be incorporated into chromatin as a metal-protein complex, but the possibility of protein-mercury-DNA or mercury-DNA complexes within euchromatin cannot be excluded.

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