Entropy of the genetic information and evolution

Details Entropy of the genetic information and evolution Entropy of the genetic information and evolution

Jan 1975

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1975orli....6..219h&link_type=abstract

Origins of Life, Volume 6, Issue 1-2, pp. 219-227

Computer Science

4

Scientific paper

The entropy of the amino acid sequences coded by DNA is considered as a measure of diversity or variety of proteins, and is taken as a measure of evolution. The DNA or m-RNA sequence is corsidered as a stationary second-order Markov chain composed of four kinds of bases. Because of the biased nature of the genetic code table, increase of entropy of amino acid sequences is possible with biased nucleotide sequence. Thus the biased DNA base composition and the extreme rarity of the base doubletC p G of higher organisms are explained. It is expected that the amino acid composition was highly biased at the days of the origin of the genetic code table, and the more frequent amino acids have tended to get rarer, and the rarer ones more frequent. This tendency is observed in the evolution of hemoglobin, cytochrome C, fibrinopeptide, immunoglobulin and lysozyme, and protein as a whole.

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