Biology – Quantitative Biology – Cell Behavior
Scientific paper
2006-05-29
Biology
Quantitative Biology
Cell Behavior
34 pages, 9 figures. This paper is accepted for publication in the Journal of Computational and Mathematical Methods in Medici
Scientific paper
We formulate and analyze a mathematical model describing immune response to avascular tumor under the influence of immunotherapy and chemotherapy and their combinations as well as vaccine treatments. The effect of vaccine therapy is considered as a parametric perturbation of the model. In the case of a weak immune response, neither immunotherapy nor chemotherapy is found to cause tumor regression to a small size, which would be below the clinically detectable threshold. Numerical simulations show that the efficiency of vaccine therapy depends on both the tumor size and the condition of immune system as well as on the response of the organism to vaccination. In particular, we found that vaccine therapy becomes more effective when used without time delay from a prescribed date of vaccination after surgery and is ineffective without preliminary treatment. For a strong immune response, our model predicts the tumor remission under vaccine therapy. Our study of successive chemo/immuno, immuno/chemo and concurrent chemoimmunotherapy shows that the chemo/immuno sequence is more effective while concurrent chemoimmunotherapy is more sparing.
Isaeva O. G.
Osipov Vladimir Al.
No associations
LandOfFree
Different Strategies for Cancer Treatment: Mathematical Modeling does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Different Strategies for Cancer Treatment: Mathematical Modeling, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Different Strategies for Cancer Treatment: Mathematical Modeling will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-168250