Four-Stranded Dna Formed by Isoguanine Quartets: Complex Stoichiometry, Thermal Stability and Resistance Against Exonucleases

Details Four-Stranded Dna Formed by Isoguanine Quartets: Complex Stoichiometry, Thermal Stability and Resistance Against Exonucleases Four-Stranded Dna Formed by Isoguanine Quartets: Complex Stoichiometry, Thermal Stability and Resistance Against Exonucleases

Dec 1997

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1997oleb...27..597s&link_type=abstract

Origins of Life and Evolution of the Biosphere, v. 27, Issue 5/6, p. 597-608 (1997).

Computer Science

Scientific paper

Single stranded DNA-fragments containing short runs of isoguanine such as d(T_4iG_4T_4) (5) or d(iG_4T_4) (6) form quartet structures by self-assembly of the isoguanine residues. The stoichiometry of the complexes is deduced from mixed aggregates formed between d(T_4iG_4T_4) and d(iG_4T_4). The iG_d-tetrads are more stable with regard to their thermal denaturation and to their resistance against enzymatic phosphodiester hydrolysis than those formed by dG.

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