Computer Science
Scientific paper
Dec 1997
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1997oleb...27..513p&link_type=abstract
Origins of Life and Evolution of the Biosphere, v. 27, Issue 5/6, p. 513-523 (1997).
Computer Science
1
Scientific paper
The oligomerization of adenosine 5'-phosphoro-4-(dimethylamino)pyridinium (4-(CH_3)_2\-NpypA) and diadenosine 5',5'-pyrophosphate (A^5'ppA) (9:1) on Na^+-montmorillonite was studied. The oligomers were isolated and analyzed by selective enzymatic hydrolyses and the oligomeric composition and the percent of 3',5'-phosphodiester linkages present in each fraction was determined. The longest oligomers formed (11-mers) are slightly shorter than those produced in the absence of A^5'ppA (12-mers). Smaller amounts of A^5'ppA are incorporated into the oligomers than in the ImpA/A^5'ppA reaction. The regioselectivity of 3',5'-phosphodiester bond formation is comparable to that of the oligomerization of 4-(CH_3)_2NpypA alone. An explanation of these data is proposed and the possible effect of dinucleoside pyrophosphate on prebiotic RNA formation is discussed.
Ferris James P.
Prabahar Joseph K.
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