Biology – Quantitative Biology – Cell Behavior
Scientific paper
2007-05-08
Proc. Natl. Acad. Sci. U.S.A. (2007), 104 (47), 18549-18554
Biology
Quantitative Biology
Cell Behavior
revised manuscript; 8 pages, 6 figures; supplementary information not included
Scientific paper
10.1073/pnas.0704235104
Hayashi and Carthew (Nature 431 [2004], 647) have shown that the packing of cone cells in the Drosophila retina resembles soap bubble packing, and that changing E- and N-cadherin expression can change this packing, as well as cell shape. The analogy with bubbles suggests that cell packing is driven by surface minimization. We find that this assumption is insufficient to model the experimentally observed shapes and packing of the cells based on their cadherin expression. We then consider a model in which adhesion leads to a surface increase, balanced by cell cortex contraction. Using the experimentally observed distributions of E- and N-cadherin, we simulate the packing and cell shapes in the wildtype eye. Furthermore, by changing only the corresponding parameters, this model can describe the mutants with different numbers of cells, or changes in cadherin expression.
Carthew Richard W.
Graner Francois
Hayashi Takashi
Käfer Jos
Marée Athanasius F. M.
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