Abnormal Serum Components after Escherichia coli Endotoxin Administration to Male and Female Rats

Details Abnormal Serum Components after Escherichia coli Endotoxin Administration to Male and Female Rats Abnormal Serum Components after Escherichia coli Endotoxin Administration to Male and Female Rats

Feb 1964

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1964natur.201..705l&link_type=abstract

Nature, Volume 201, Issue 4920, pp. 705-706 (1964).

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PREVIOUS investigations1,2 have established that intra-peritoneal injection of cadmium chloride into rats was followed 24 h later by the appearance in the serum of an abnormal component, identified as a distinct band on starch-gel electrophoresis and designated A.S.C. This component reached a maximum concentration in the serum at 48 h following a single dose and gradually decreased over the subsequent 7 days. Other metallic salts at a similar dose rate were tested in an identical manner. At a level of 1 mg/kg, the following sequence of effectiveness was observed: mercury > beryllium, cadmium, copper > manganese > chromium, nickel > iron, cobalt. Lead had no effect.

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